Neo-T: Autologous Mutant Neoantigen-Specific, TCR-Engineered T Cells For Adoptive Cellular Therapy

Inventor(s):

    SUMMARY

    • Selecting appropriate antigens on cancers is critical for development of T cell-based cellular therapies. Because of the enormous number/diversity of cancers it is impossible to clearly identify tumor antigens that can function as targets across different tumor entities and large groups of patients. 
    • Inventors at the University of Chicago have developed a proprietary platform called “Neo-T” allowing the use of mutant neoantigens from an individual’s own cancer cells as a target structure for adoptively transferred T cells. The technology is based on the selection of a suitable pair of T cell receptors (TCRs) that can recognize neoantigens presented by patient MHC molecules.
    • To achieve tumor eradication, one of the two TCRs must recognize a neoantigen in the context of an MHC class I molecule, and the other in the context of an MHC class II molecule. To increase the number/availability of neoantigen-specific T cells in a patient before TCR isolation, a vaccination strategy was developed using non-malignant surrogate cancer cells (SCCs) from the patient. Proof-of-principle studies demonstrated complete eradication of large and long-established solid tumors in mice.

    FIGURE

    Neo-T therapy’s 3-step process: identification of mutant neoantigens and production of SCCs, isolation of neoantigen-specific T cells from patient tumor-infiltrating lymphocytes or peripheral blood (SCC vaccination may be required), and adoptive therapy using T cells created with neoantigen-specific TCRs. 

    ADVANTAGES

    ADVANTAGES

    • Universal, personalized T-cell cancer treatment

    • Selection of optimal TCRs in the context of both MHC I & II

    • Enhanced safety and minimized unpredictable cross-reactivity are eliminated which may be encountered when using TCRs from other sources

     

    APPLICATIONS

    • Adoptive T cell therapies for cancer

    • Cancer vaccine

    • Preclinical – in vivo

    TECH DETAILS

    Published
    1/31/2022

    Reference ID
    21-T-088

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    Michael Hinton

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