Computational Method to Design Simultaneous Radiation Treatment of Multiple Metastatic Lesions

SUMMARY

• Stereotactic ablative body radiotherapy (SART) is the precise delivery of concentrated radiation beams to a tumor from different angles. Due to the cross interaction between beams, SART is rarely able to be applied in the simultaneous treatment of multiple metastatic lesions, despite the potential benefit to patients who have significant tumor burden at several sites.
• The investigators developed an algorithm that scores individual SART beam angles by the ratio of radiation dose delivered to the target tumor as compared to the surrounding healthy tissue. Beam angles that do not target tumors are automatically removed from consideration, and a combination of beams that deliver the highest radiation dose to all the target tumors with the lowest off-target impact to healthy tissue is calculated, thus enabling the implementation of SART to simultaneously treat of multiple metastatic lesions.
• The product is an algorithm and software. Physicians input a patient CT scan and target tumor radiation dose and receive suggested SART beam angles as an output. The physician can then use the suggested beam angles to generate a patient specific radiotherapy treatment plan.
• A prototype software package has been developed, and can successfully generate SART beam angles for patients with up to three distinct tumor sites. The algorithm ensures that all tumor tissue receives radiation doses at least 5 times greater than the surrounding healthy tissue.

FIGURE

Algorithm beam selections for a 3-tumor patient simulation (left) and a 10-tumor patient simulation (right). In each case, tumors receive at least 5 times greater a radiation dose than the surrounding healthy tissue.

ADVANTAGES

ADVANTAGES

• Works with multiple tumor sites; prior radiotherapy planning software is only used for single sites
• Significantly reduces overall treatment planning time
• Can be used for tumors across the patient’s body
• Physician can input patient specific parameters to avoid organ risk
• Physician controls final treatment design
• Automatically eliminates hazardous beams

APPLICATIONS

• Precision medicine/Digital health
• Radiation oncology

PUBLICATIONS

• Chmura, S; et al. NRG-BR001 (NCT02206334): A Phase 1 Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of Multiple Metastases. ClinicalTrials.gov
• AlHallaq, HA; et al. Rationale of technical requirements for NRG-BR001: The first NCI-sponsored trial of SBRT for the treatment of multiple metastases. Pract Radiat Oncol. 2016 May 20.

June 30, 2019

Prototype (up to three distinct tumor lesions)

Patent Pending

Licensing,Co-development,Investment

Steven Chmura