Available Technologies   //   Invention Disclosure

Tech at Polsky

BACK TO SEARCH RESULTS

Self-assembling Nanofibril Particles for Controlled Release of IV and SUBQ Therapeutics

Inventor(s):

Technology Classifications > Therapeutics

    SUMMARY

    • Clinically approved methods for the controlled release of oral therapies have demonstrated their efficacy in reducing required dosage, administration frequency, and side effects, thereby boosting patient compliance. Despite these successes, no solution is available for the controlled release of intravenously and subcutaneously administered therapies.
    • The inventors synthesized copolymers composed of hydrophilic PEG and hydrophobic oligo(ethyl sulfide) (OES) blocks which self-assemble in aqueous solution to form two or three dimensional high aspect ratio nanofibril structures. Drug cargo can either be dissolved within the polymer, or covalently attached. The specific fibril structure and conditions that induce its disassembly can be tuned by altering the copolymer composition. 
    • The inventors injected various mouse models with the nanoparticles conjugated with fluorophore. They showed that the particles formed a depot at the injection site, are delivered to the lymph nodes via flow and cellular methods and are delivered to tumor tissue and tumor associated immune cells. This demonstration emphasizes the applicability of the invention in cancer therapeutics and vaccines. 

     

    FIGURE

    In vivo proof-of-concept experiment showing that nanoparticles can either remain at the injection site and form a depot or target cargo to the lymph nodes depending on functionalization. Mice were injected with 100ug fluorescent nanoparticle with or without 10ug of Toll-like receptor ligand CpG-B. Only CpG-B conjugated nanoparticles targeted the lymph nodes and the unfunctionalized nanoparticles remained at the injection site.

     

     

    ADVANTAGES

    ADVANTAGES

    • Programmable release conditions
    • Programmable size and shape
    • More control over depot formation than standard formulations

     

    APPLICATIONS

    • Intravenous and subcutaneous drug formulation
    • Oncology therapeutics
    • Vaccines
    • Research tool (immunology, oncology, pharmacokinetics)

     

    • PCT/US2014/048009

    TECH DETAILS

    Published
    7/23/2019

    Reference ID
    15-T-079

    Have Questions?

    Michael Hinton

    Contact Michael Hinton, Manager, Technology Marketing, who can provide more detail about this technology, discuss the licensing process, and connect you with the inventor.

    This site uses cookies and other tracking technologies to assist with navigation and your ability to provide feedback, analyze your use of products and services, assist with our promotional and marketing efforts.

    Accept
    [%Analytics%]