SUMMARY
Groundbreaking advancement in the field of mRNA topical delivery systems, providing superior penetration, stability, and biocompatibility compared to existing solutions. It opens up new possibilities for both therapeutic and cosmetic applications, paving the way for more effective and user-friendly treatments.
The unmet need: Strategy for stable non-immunogenic topical mRNA delivery
- RNA delivery is a rapidly evolving area within the broader domain of drug delivery systems. mRNA therapeutics have garnered significant interest due to their potential to instruct cells to produce specific proteins that can combat a wide range of diseases. Unlike traditional drugs, which typically involve administering therapeutic proteins directly, mRNA therapies leverage the body's cellular machinery to produce these proteins endogenously, offering a versatile approach to treatment.
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Current technologies for delivering mRNA include various vectors such as lipid nanoparticles (LNPs), viral vectors, and polymers. These technologies have demonstrated functionality in delivering mRNA vaccines and therapeutics systemically via injections. Also, these delivery techniques are limited by potential safety concerns including immunogenicity, stability, and efficiency of delivery.
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Topical delivery remains a challenging area due to the protective barrier function of the skin that restricts the penetration and effective delivery of therapeutic molecules into deeper skin layers. Lipid-based vesicles designed to enhance skin penetration still face limitations in payload capacity and stability. Hydrogels can be used to encapsulate mRNA and enhance delivery but maintaining mRNA integrity and ensuring deep penetration remain issues.
The proposed solution: Novel noninvasive, multihydroxy-propane topical delivery system for mRNA cargo across the skin to express specific protein
- The faculty inventor developed a novel multihydroxy-propane vesicle system combined with a polymeric gel for the topical delivery of mRNA. This system is innovatively designed to address the challenges associated with delivering mRNA through the skin. The multihydroxy-propane vesicles encapsulate the mRNA, creating a stable and protective environment and with integration into a polymeric gel, produce a uniform and thick cream that can be easily applied to the skin.
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Upon application, the cream spreads smoothly over the skin, allowing the vesicles to penetrate the stratum corneum. The vesicles facilitate the transport of mRNA into deeper skin layers, where it can be taken up by cells and translated into therapeutic proteins.
ADVANTAGES
ADVANTAGES
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Significantly improved delivery and penetration of mRNA through the skin’s barrier
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Biocompatible components reducing the risk of adverse immune responses
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Non-invasive stable delivery
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Ease of application, formulation as a cream promotes better user compliance
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System allows for a sustained release of mRNA enhancing the duration of therapeutic effects
APPLICATIONS
- Cosmetic treatments
- Dermatology
- Gene therapy
- Topical delivery of mRNA vaccines
- Wound healing
November 13, 2024
Proof of concept
Patent Pending
Licensing,Co-development
Xiaoyang Wu