Adenosine Deamination Sequencing to Map Methylated Adenosine at Single-Nucleoside Resolution

SUMMARY

• The detection of epigenetic marks on RNA is a specific area of interest for researchers and clinicians as these marks correspond to effects on gene expression.  
• The work of the faculty inventor is applicable to the current market of transcriptomics, biomarker discovery, and toxicogenomics as there has been a number of increasing applications of RNA sequencing and significant research efforts in RNA analysis.    
• The faculty inventor has presented a novel method of mapping N6-methyladenosine (m6A), the most abundant internal modification in messenger RNA, in a transcriptome-wide manner at a single-nucleoside resolution that specifically localizes m6A in the transcriptome. 
• The single-nucleoside resolution detection and quantitative analyses of methylation across the entire transcriptome is of great importance to further investigate the biological significance of the methylation modification and is an excellent tool for RNA research laboratories. 

ADVANTAGES

ADVANTAGES

• Localization of the m6A-seq and modification within transcripts that provide a direct conversion tool 
• Detection of epigenetic marks on RNA which is a significant breakthrough in the field of gene expression 

APPLICATIONS

• Sequencing technologies 
• Highly sensitive and single base resolution mapping of RNA modifications 
• Gene expression research

Feb 23, 2023

Licensing,Co-development

Patent Issued

Proof of concept

Chuan He